Federer out; Isner, Nadal and Djokovic advance

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LONDON (AP) -- Defending champion Roger Federer has been knocked out of Wimbledon after wasting a match point in the third set. The defending champion lost to Kevin Anderson of South Africa, 2-6, 6-7, 7-5, 6-4, 13-11.

John Isner has reached his first Grand Slam semifinal on his 41st appearance. The hard-serving American beat Milos Raonic of Canada 6-7, 7-6, 6-4, 6-3 to set up a meeting with Anderson in Wimbledon's last four.

Isner's 41 attempts to make a semifinal at a major is the second most in the 50-year professional era, behind Sam Querrey, who made the last four at Wimbledon last year with his 42nd try.

Top-ranked Rafael Nadal outlasted Juan Martin del Potro in a five-set duel to reach his first Wimbledon semifinal since 2011. Nadal came from a set down to win 7-5, 6-7, 4-6, 6-4, 6-4 in 4 hours, 48 minutes - the longest match of this year's tournament.

Novak Djokovic beat Kei Nishikori 6-3, 3-6, 6-2, 6-2.