An overturned 18-wheeler carrying 7,800 gallons of jet fuel blocked both lanes of Texas 36 between Caldwell and Milano Thursday morning.
Both north and southbound vehicles were turned away for several hours at the scene, four miles south of Milano.
An estimated 4,000 gallons of jet fuel leaked into the road. Emergency crews spent more than three hours cleaning it up.
The accident happened about 7 a.m. Texas 36 reopened about 10:30 a.m. No injuries were reported.
Hazardous materials crews from Bryan and College Station were originally called in to assist at the scene until a Houston-based clean-up crew could arrive. That call for B-CS responders was later canceled.