The American Heart Association says nearly all U.S. women are in danger of heart disease or stroke and should be more aggressive about lowering their risk.
The Dallas-based association reports that includes asking their doctors about daily aspirin use.
It's the first time guidelines have urged all women to consider aspirin for preventing strokes, although specialists warn that it can cause ulcers and dangerous bleeding.
The guidelines also advise daily exercise and less fat -- and declare vitamins C and E, beta carotene and folic acid supplements worthless for preventing heart disease.
The guidelines aim to get women and doctors to focus on the long-term risk of high blood pressure, smoking, lack of exercise or being overweight.
Details are in the journal Circulation.