The Romney campaign has paid for the 54-second spot, which opens with the president at a White House press conference.
The ad shows eight people talking about their experiences: staff cuts, job loss, personal bankruptcy, a two-year job hunt, no healthcare and a slashed pension and other concerns. The ad closes with, "No, Mr. President, we are not doing fine."
Romney is using Obama's remark to cast the president as out of touch with the average American, a criticism the president's campaign has tried against Romney.
The economy with its stubborn 8.2 percent unemployment is the biggest issue for voters and a weak spot for Obama.
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