DURHAM, North Carolina (AP) -- Megan Rogowski scored 22 points and Megan Podkowa added 18 to help DePaul upset Duke 74-65 on Monday night in the second round of the NCAA tournament.
Brittany Hrynko added 14 for the seventh-seeded Blue Demons (29-6). They earned their third appearance in the round of 16 by hitting 14 3-pointers and forcing second-seeded Duke into 21 turnovers with their high-pressure defense.
DePaul will play the James Madison-Texas A&M winner on Saturday in the Lincoln Regional semifinals.
Elizabeth Williams scored 12 points, and seniors Haley Peters and Tricia Liston each added 11 in their final game at Cameron Indoor Stadium.
Duke (28-7) led for only 12 seconds and became the first top-four seed to lose in the tournament.
The Blue Devils - who made four straight appearances in the regional finals - became the first No. 2 seed to lose this early since Xavier lost to Louisville in 2011.
DePaul now awaits the winner between Texas A&M - James Madison that will be played Tuesday night in College Station.